What is behind Restless Legs & Night Twitches
Cardiac excitation-contraction coupling — the calcium cycling that every inotrope and every physiological lever ultimately works through. Evidence A — Human trial evidence.
Mitochondrial energy (ATP) output. Evidence A — Human trial evidence.
GABA — the brain's principal inhibitory neurotransmitter, the source of calm and restful sleep. Evidence A — Human trial evidence.
Evidence on these pathways
GABA → Mood (Positive Affect). “In this review, we summarize clinical and preclinical evidence supporting a central and causal role of GABAergic deficits in the etiology of depressive disorders.” — The GABAergic deficit hypothesis of major depressive disorder. Molecular Psychiatry, 2011, vol 16, issue 4, pp 383-406. doi:10.1038/mp.2010.120
Formulas that act on these pathways
Acts on 1 of these pathways: Calcium Handling.
What this page does not claim
This page names the pathways involved and the published evidence on each. It does not claim that any formula treats, cures or prevents Restless Legs & Night Twitches. A pathway opens here only on graded, published evidence, under a standard fixed before the evidence was gathered, and every figure above carries its grade.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.