Vitamin D, 25-OH
Reads: Vitamin D status
The mr literature is a cautionary case: bidirectional mr supports causal relationships with psoriasis, atopic dermatitis and vitiligo, while a vitamin D dose-response mr for coronary heart disease, stroke and all-cause mortality is listed as retracted.
What this marker reads
A hormone misfiled as a vitamin. And the finding that governs every claim on it here: the updated meta-analysis of vitamin D for acute respiratory infection — adding 20 further RCTs and 62,063 participants to the earlier individual-participant analysis — returned a 95% confidence interval that now includes 1.00, meaning no statistically significant protection overall. What survives is the stratification: the effect was stronger in those starting with lower vitamin D, and with daily or weekly dosing rather than widely spaced bolus doses. Correcting a shortfall and topping up someone already replete are different acts.
What a named body publishes
Each line below is the sentence the issuing body wrote, carried with its own identifier. Nothing here interprets your result — it states what was published, for whom, and by whom.
25-hydroxyvitamin D
“Serum 25(OH)D below 30 nmol/L is 'Associated with vitamin D deficiency, which can lead to rickets in infants and children and osteomalacia in adults'.”
Vitamin D — Health Professional Fact Sheet · NIH Office of Dietary Supplements The document
“Serum 25(OH)D below 12 ng/mL is 'Associated with vitamin D deficiency, which can lead to rickets in infants and children and osteomalacia in adults'.”
Vitamin D — Health Professional Fact Sheet · NIH Office of Dietary Supplements The document
“Serum 25(OH)D of 30 to less than 50 nmol/L is 'Generally considered inadequate for bone and overall health in healthy individuals'.”
Vitamin D — Health Professional Fact Sheet · NIH Office of Dietary Supplements The document
“Serum 25(OH)D of 12 to less than 20 ng/mL is 'Generally considered inadequate for bone and overall health in healthy individuals'.”
Vitamin D — Health Professional Fact Sheet · NIH Office of Dietary Supplements The document
“Serum 25(OH)D of 50 nmol/L and above is 'Generally considered adequate for bone and overall health in healthy individuals'; the page's text adds that 'Levels of 50 nmol/L (20 ng/mL) or more are sufficient for most people'.”
Vitamin D — Health Professional Fact Sheet · NIH Office of Dietary Supplements The document
“Serum 25(OH)D of 20 ng/mL and above is 'Generally considered adequate for bone and overall health in healthy individuals'.”
Vitamin D — Health Professional Fact Sheet · NIH Office of Dietary Supplements The document
“Serum 25(OH)D above 125 nmol/L is 'Linked to potential adverse effects, particularly at >150 nmol/L (>60 ng/mL)'.”
Vitamin D — Health Professional Fact Sheet · NIH Office of Dietary Supplements The document
“Serum 25(OH)D above 50 ng/mL is 'Linked to potential adverse effects, particularly at >150 nmol/L (>60 ng/mL)'.”
Vitamin D — Health Professional Fact Sheet · NIH Office of Dietary Supplements The document
Your laboratory reads your result against its own assay, and this page does not do that for it. What is above is what a named body published and for whom; the machinery this marker reads is set out on its pathway page, and the formulas witnessed on it are below.
The machinery behind it
What raises this marker and what it goes on to move — each edge carried with its own study — is set out in full on its pathway page: Vitamin D status →
Formulas that modulate it
Each formula page names this pathway and carries the study behind its claim.
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