SHBG
Reads: Hormone-binding protein
You want it high: abundant SHBG sequesters DHT, and because insulin suppresses SHBG, protecting insulin sensitivity is how you keep this buffer full.
What this marker reads
The liver-made carrier protein that binds circulating sex hormones — the buffer that decides how much androgen is free to reach the follicle.
What a named body publishes
Each line below is the sentence the issuing body wrote, carried with its own identifier. Nothing here interprets your result — it states what was published, for whom, and by whom.
SHBG
“In the simplified sex- and age-specific reference interval the authors adopted, SHBG in men aged 20-49 years ranged 12.3-79.6 nmol/L.” males, 20-49
Definition, Prevalence, and Risk Factors of Low Sex Hormone-Binding Globulin in US Adults · The Journal of Clinical Endocrinology & Metabolism · 2021 DOI 10.1210/clinem/dgab416 · PMID 34125885
“In the simplified sex- and age-specific reference interval the authors adopted, SHBG in men aged 50-80 years ranged 23.5-114.7 nmol/L.” males, 50-80
Definition, Prevalence, and Risk Factors of Low Sex Hormone-Binding Globulin in US Adults · The Journal of Clinical Endocrinology & Metabolism · 2021 DOI 10.1210/clinem/dgab416 · PMID 34125885
“In the simplified sex- and age-specific reference interval the authors adopted, SHBG in women aged 20-29 years ranged 14.5-249.8 nmol/L.” females, 20-29
Definition, Prevalence, and Risk Factors of Low Sex Hormone-Binding Globulin in US Adults · The Journal of Clinical Endocrinology & Metabolism · 2021 DOI 10.1210/clinem/dgab416 · PMID 34125885
“In the simplified sex- and age-specific reference interval the authors adopted, SHBG in women aged 30-80 years ranged 21.9-186.0 nmol/L.” females, 30-80
Definition, Prevalence, and Risk Factors of Low Sex Hormone-Binding Globulin in US Adults · The Journal of Clinical Endocrinology & Metabolism · 2021 DOI 10.1210/clinem/dgab416 · PMID 34125885
Your laboratory reads your result against its own assay, and this page does not do that for it. What is above is what a named body published and for whom; the machinery this marker reads is set out on its pathway page, and the formulas witnessed on it are below.
The machinery behind it
What raises this marker and what it goes on to move — each edge carried with its own study — is set out in full on its pathway page: Hormone-binding protein →
Formulas that modulate it
Each formula page names this pathway and carries the study behind its claim.
Build a combo from your panel
Open the bloodwork builder and select every marker your lab flagged — it covers the most machinery with the fewest formulas.