Bloodwork

Folate and B12 (one-carbon)

Where Vitamins Become Epigenetics

1 formula on this site modulates this pathway.

The route from a vitamin to an epigenetic mark. Folate, B12 and B6 feed this cycle; the cycle supplies the methyl groups that DNA methylation runs on. The mthfr variants that dominate consumer genetics sit here, and their effect is on this cycle, not on methylation directly.

What this marker reads

The folate and B12 cycle that carries single carbon units for methylation and nucleotide synthesis.

What a named body publishes

Each line below is the sentence the issuing body wrote, carried with its own identifier. Nothing here interprets your result — it states what was published, for whom, and by whom.

Serum folate

“WHO defines folate deficiency on the metabolic (homocysteine) indicator as "serum or plasma folate lower than 4 ng/mL (10 nmol/L)", for all age groups.”

World Health Organization, eCatalogue of indicators for micronutrient programmes - folate status as measured by serum or plasma folate, citing WHO Vitamin and Mineral Nutrition Information System, Serum and red blood cell folate concentrations for assessing folate status in populations (WHO/NMH/NHD/EPG/15.01) · World Health Organization eCatalogue of indicators for micronutrient programmes — the entry itself carries no date; WHO/NMH/NHD/EPG/15.01 is the cited source · 2015 The document

“WHO defines folate deficiency on the haematological (macrocytic anaemia) indicator as "serum or plasma folate lower than 3 ng/mL (6.8 nmol/L)", for all age groups.”

Red blood cell folate

“WHO defines red blood cell folate deficiency as "lower than 151 ng/mL (340 nmol/L)" on the homocysteine-based definition, for all age groups.”

World Health Organization, eCatalogue of indicators for micronutrient programmes - red blood cell folate, citing WHO Vitamin and Mineral Nutrition Information System, Serum and red blood cell folate concentrations for assessing folate status in populations (WHO/NMH/NHD/EPG/15.01) · World Health Organization eCatalogue of indicators for micronutrient programmes — the entry itself carries no date; WHO/NMH/NHD/EPG/15.01 is the cited source · 2015 The document

“WHO defines red blood cell folate deficiency on the macrocytic-anaemia-based definition as "lower than 100 ng/mL (226.5 nmol/L)", for all age groups.”

“WHO defines red blood cell folate insufficiency in women of reproductive age as "400 ng/mL (906 nmol/L) or lower", the threshold tied to neural tube defect risk.” females, women of reproductive age

Vitamin B12

“The fact sheet states that "most laboratories define subnormal serum or plasma values as those lower than 200 or 250 pg/mL (148 or 185 pmol/L)"; 148 pmol/L (200 pg/mL) is the lower of the two definitions.”