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Plant

Notoginseng

Panax notoginseng

Notoginseng (Panax notoginseng)
Interstellar grade B

Preclinical: Mechanistic, cell or animal evidence. No single preclinical driver opens a pathway on its own.

Appears on 7 blend pages, each linked below.

Tianqi, the notoginseng root, lends saponins that steady blood flow through the retina and seal the micro-vessels against bleeding.

Traditional reading

San Qi三七Traditional Chinese medicine

Given to stop bleeding, break up bruising, and relieve swelling and pain after a fall or blow.

Source: ShennongAlpha NMM-002W, Chinese Pharmacopoeia 2020 | Duan L et al. Front Pharmacol 2017;8:702 (Bencao Gangmu)

A traditional reading, held separate from the graded evidence above. It opens no pathway.

What the evidence shows

Every line below is carried on the blend page that makes the claim. Follow it to the pathway and its sources.

Panax notoginseng oligosaccharides reversed replicative senescence in human dermal fibroblasts — lowering SA-β-gal, p16 and p21 and restoring proliferation and collagen synthesis — shown in laboratory study.

Senolytic (Senescent Zombie Cell Clearance) →

Notoginseng's activity lives in three of its saponins, and in animal heart and nerve models those constituents raise SIRT1.

SIRT1 Activator (Caloric-Restriction Mimetic) →

Cultured cells given notoginseng show the p53 alarm sounding, division pausing at its checkpoint, the growth relay quieting, the clean-up crew clearing damaged parts, and the oxidative balance shifting.

ACB (Cell-Cycle Checkpoint Restraint) →

In sleep-deprived mice, saponins from notoginseng stem and leaf improved spatial learning and memory in the water maze.

ALZ (Memory Preservation) →

Sanchi root's saponins guard the fine vessels of the retina, keeping their walls sealed against leakage so the eye's picture stays clear.

NAD+ Booster (Cellular Energy Currency) →

Ginsenoside Rg1 cut thrombin-driven human platelet aggregation and reduced arterial thrombus in vivo.

Thrombolytic (Hemostatic Balance) →

Where it appears

7 blend pages carry this ingredient. Open it and you will find this ingredient in the list.

Pathways it touches

Diabetic Retinopathy NF-κB
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